5-Amino-1MQ (5-amino-1-methylquinolinium) is a cell-permeable small-molecule compound, distinct from the peptides elsewhere in our catalog, that functions as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that methylates nicotinamide using S-adenosylmethionine (SAM) as the methyl donor.
NNMT sits at a metabolic crossroads relevant to several other compounds in our catalog: by consuming nicotinamide, it diverts a resource that would otherwise be available to the NAD+ salvage pathway, the same NAD+ system studied in our NAD+ entry. 5-Amino-1MQ competitively occupies NNMT's active site, blocking this conversion. The downstream consequence is twofold: more SAM remains available for methylation reactions relevant to gene expression in adipocytes, and more nicotinamide is preserved for NAD+ regeneration via NAMPT, supporting sirtuin activity and mitochondrial oxidative phosphorylation. NNMT is notably overexpressed in obese adipose tissue, positioning 5-Amino-1MQ as a research tool for studying adipocyte-specific metabolic reprogramming, distinct mechanistically from receptor-based metabolic compounds such as AOD9604 or the GLP-1 family.
Product Specifications
Purity: >99%, verified via HPLC
Form: Lyophilized powder
Vial Size: Multi-dose vial (supports up to 3ml reconstitution)
Reconstitution & Storage
Intended Use: For laboratory research purposes only. Reconstitution with Bacteriostatic Water (BAC water) is required before use.
Storage: Store lyophilized powder in a cool, dry place away from light. After reconstitution, keep refrigerated at 2-8°C.
Solubility: Reconstitute with BAC water. Gently swirl to dissolve, do not shake.
Shelf Life: Lyophilized form has a shelf life of up to 24 months. Once reconstituted, recommended use within 4-6 weeks.
Handling: Use sterile techniques to maintain product stability and integrity.
Important Notice
This product is intended for laboratory and research use only. It is not for human or veterinary consumption, and is not approved for use as a food, drug, cosmetic, or household chemical. Baldena Biolabs does not condone or support self-administration of this product. By purchasing, you confirm you are a qualified researcher or research institution and accept full responsibility for safe and legal handling in accordance with applicable laws.
