LL-37

LL-37 is a 37-amino-acid amphipathic alpha-helical peptide and the only cathelicidin antimicrobial peptide found in humans. It is generated through proteolytic cleavage of its 18-kDa precursor protein, hCAP18, and is naturally produced by neutrophils, macrophages, and epithelial cells as part of the innate immune defense system.

LL-37's research relevance stems from a dual mechanism distinct from receptor-mediated peptides elsewhere in our catalog. Its primary antimicrobial action occurs through direct, physical disruption of microbial cell membranes, an amphipathic structure that inserts into and destabilizes bacterial lipid membranes rather than acting through a specific binding target. Independently of this membrane-disrupting activity, LL-37 also functions as an immune modulator, interacting with cell-surface receptors such as FPRL-1 to influence neutrophil and monocyte chemotaxis, modulate inflammatory cytokine release, and contribute to wound-healing processes through effects on cell proliferation and migration. This combination of direct antimicrobial action and immunomodulatory signaling makes LL-37 a frequently studied compound in antimicrobial resistance and innate immunity research.

Product Specifications

Purity: >99%, verified via HPLC
Form: Lyophilized powder
Vial Size: Multi-dose vial (supports up to 3ml reconstitution)

Reconstitution & Storage

Intended Use: For laboratory research purposes only. Reconstitution with Bacteriostatic Water (BAC water) is required before use.

Storage: Store lyophilized powder in a cool, dry place away from light. After reconstitution, keep refrigerated at 2-8°C.

Solubility: Reconstitute with BAC water. Gently swirl to dissolve, do not shake.

Shelf Life: Lyophilized form has a shelf life of up to 24 months. Once reconstituted, recommended use within 4-6 weeks.

Handling: Use sterile techniques to maintain product stability and integrity.

Important Notice

This product is intended for laboratory and research use only. It is not for human or veterinary consumption, and is not approved for use as a food, drug, cosmetic, or household chemical. Baldena Biolabs does not condone or support self-administration of this product. By purchasing, you confirm you are a qualified researcher or research institution and accept full responsibility for safe and legal handling in accordance with applicable laws.