PE-22-28

PE-22-28 is a synthetic 7-amino-acid peptide (sequence GVSWGLR) developed as an optimized analog of spadin, a naturally occurring peptide fragment derived from the propeptide of sortilin during its processing in the Golgi apparatus. PE-22-28 represents a distinct mechanistic category within our catalog: rather than acting as a receptor agonist, it functions as a selective ion channel inhibitor.

The compound's primary target is TREK-1 (TWIK-related potassium channel 1), a two-pore-domain potassium channel expressed in neurons of the hippocampus, cortex, and raphe nuclei, brain regions central to mood regulation. TREK-1 contributes to background potassium conductance that stabilizes neuronal resting membrane potential; genetic knockout studies have shown that mice lacking TREK-1 are resistant to depressive-like states in standard behavioral models. PE-22-28 was engineered from spadin's sequence to achieve substantially improved TREK-1 binding affinity (IC50 approximately 0.12 nM, compared to 40-60 nM for spadin) and extended plasma stability, making it a more potent and durable tool for studying TREK-1-mediated neuronal excitability and its downstream effects on hippocampal neurogenesis.

Product Specifications

Purity: >99%, verified via HPLC
Form: Lyophilized powder
Vial Size: Multi-dose vial (supports up to 3ml reconstitution)

Reconstitution & Storage

Intended Use: For laboratory research purposes only. Reconstitution with Bacteriostatic Water (BAC water) is required before use.

Storage: Store lyophilized powder in a cool, dry place away from light. After reconstitution, keep refrigerated at 2-8°C.

Solubility: Reconstitute with BAC water. Gently swirl to dissolve, do not shake.

Shelf Life: Lyophilized form has a shelf life of up to 24 months. Once reconstituted, recommended use within 4-6 weeks.

Handling: Use sterile techniques to maintain product stability and integrity.

Important Notice

This product is intended for laboratory and research use only. It is not for human or veterinary consumption, and is not approved for use as a food, drug, cosmetic, or household chemical. Baldena Biolabs does not condone or support self-administration of this product. By purchasing, you confirm you are a qualified researcher or research institution and accept full responsibility for safe and legal handling in accordance with applicable laws.