PT141

PT-141 (bremelanotide) is a synthetic cyclic heptapeptide derived from alpha-melanocyte-stimulating hormone (α-MSH), developed as a structurally refined analog of Melanotan II with a distinct receptor selectivity profile. Where Melanotan II is a non-selective agonist across multiple melanocortin receptor subtypes, PT-141 was engineered to concentrate activity at MC3R and MC4R, the receptor subtypes most densely expressed in hypothalamic and limbic brain regions, while substantially reducing activity at MC1R, the receptor responsible for pigmentation effects.

In laboratory settings, PT-141 is studied as a research tool for investigating central nervous system melanocortin receptor pharmacology. Receptor binding triggers Gs-protein coupling, adenylyl cyclase activation, and downstream cAMP/PKA signaling, with secondary engagement of the ERK/MAPK pathway in neuronal populations. This central receptor mechanism distinguishes PT-141 from peripherally-acting compounds, making it a reference peptide in melanocortin system research, hypothalamic signaling studies, and comparative receptor pharmacology models.

Product Specifications

Purity: >99%, verified via HPLC
Form: Lyophilized powder
Vial Size: Multi-dose vial (supports up to 3ml reconstitution)

Reconstitution & Storage

Intended Use: For laboratory research purposes only. Reconstitution with Bacteriostatic Water (BAC water) is required before use.

Storage: Store lyophilized powder in a cool, dry place away from light. After reconstitution, keep refrigerated at 2-8°C.

Solubility: Reconstitute with BAC water. Gently swirl to dissolve, do not shake.

Shelf Life: Lyophilized form has a shelf life of up to 24 months. Once reconstituted, recommended use within 4-6 weeks.

Handling: Use sterile techniques to maintain product stability and integrity.

Important Notice

This product is intended for laboratory and research use only. It is not for human or veterinary consumption, and is not approved for use as a food, drug, cosmetic, or household chemical. Baldena Biolabs does not condone or support self-administration of this product. By purchasing, you confirm you are a qualified researcher or research institution and accept full responsibility for safe and legal handling in accordance with applicable laws.