Snap-8

Snap-8 (acetyl octapeptide-3) is a synthetic eight-amino-acid peptide developed as an extension of the earlier compound Argireline, designed to target the SNARE complex, the molecular machinery responsible for neurotransmitter vesicle fusion at the neuromuscular junction.

Snap-8 mimics a fragment of SNAP-25, one of the three core proteins (alongside syntaxin and VAMP/synaptobrevin) that assemble into the SNARE complex to enable acetylcholine release. By competitively occupying SNAP-25's binding position within this complex, Snap-8 reduces the proportion of fully assembled SNARE complexes per neural signal, attenuating, rather than blocking, acetylcholine-mediated vesicle fusion. This produces a partial, reversible, dose-dependent reduction in neurotransmitter release. The distinction is mechanistically important relative to Botulinum Toxin, also available in our catalog: Botulinum Toxin acts enzymatically, cleaving SNAP-25 to produce near-complete and longer-lasting blockade, while Snap-8's competitive, non-enzymatic mechanism is reversible once the peptide is no longer present.

Product Specifications

Purity: >99%, verified via HPLC
Form: Lyophilized powder
Vial Size: Multi-dose vial (supports up to 3ml reconstitution)

Reconstitution & Storage

Intended Use: For laboratory research purposes only. Reconstitution with Bacteriostatic Water (BAC water) is required before use.

Storage: Store lyophilized powder in a cool, dry place away from light. After reconstitution, keep refrigerated at 2-8°C.

Solubility: Reconstitute with BAC water. Gently swirl to dissolve, do not shake.

Shelf Life: Lyophilized form has a shelf life of up to 24 months. Once reconstituted, recommended use within 4-6 weeks.

Handling: Use sterile techniques to maintain product stability and integrity.

Important Notice

This product is intended for laboratory and research use only. It is not for human or veterinary consumption, and is not approved for use as a food, drug, cosmetic, or household chemical. Baldena Biolabs does not condone or support self-administration of this product. By purchasing, you confirm you are a qualified researcher or research institution and accept full responsibility for safe and legal handling in accordance with applicable laws.